Santalol compound.



erases,

eiarrn sr'r airs RUDOLPH BERENDES, 0F ELBERFELD, GER/MANY, ASSIGNOR T0 FARBENFABRIKEN J HORNE. FBIEDR. BAYER 8c 00., 0F ELBERFELID, GERMANY, A CORPORATION 015" GERMANY.

SANTALQL conrounn. I

lie brewing.

To all whom it may concern. 7

Be it known that I, RUDOLPH BERENDES,

doctor of philosophy, chemist, citizen of the.

German Empire, residing at E lberfeld, Germany, have invented new and usefullm- ,6 tions that they form solid salts with acids which are odorless and easily absorbed by the human body. They are especially quallfied for the treatment of gonorrhea, cystitis,

etc., an average dose being between'02 to 0.5 gram. The process for producing the I, new compounds consists in treating halogen aoetyl compounds of 'santalol from 'oil of, santal JWll1ll secondary amins according as the following equation:

' the parts being by weight-220 partmiof" santalol are converted into chloroacetylsantalol by treating it with chloroacetyl chlorid and pyridin or with chloroacetic acid, phosgene and pyridin. The chloroacetyl santalol thus produced is a thick oil. It is mixed while'cooling with 90 parts of dimethylamin dissolved in benzene andfthe ,mixture is allowed 'to stand for 24: hours.

Specification of Letters Patent. Application filed April 28, 1910. Serial No. 558,156. (Specimens) Patented knee. 27, two.

Subsequently the dimethylamin hydrochlorid separated is filtered oil and the benzene solution is shaken with dilute hydrochloric acid in order to dissolve the dimethylaminoacetylsantalol. This compound is then isolated by adding a solution of sodium carbonate to the hydrochloric-acid solution. It is a ycllowish odorless oil. Itshydrochlorid crystallizes from acetone in the shape of tasteless and odorless needles melting at 154 C. which are solublein water too limpid solution of an acid reaction. One can also start from oil of santal in which case the procedure remains the same. 1 Other secondary amine such as diethylamin. can be. used.

1. The herein described new alkyl-amino acetic acid esters of santalol, obtainable by treating chloroacetyl santalol with a seconda-ry amin, which are oils soluble in alcohol and ether and insoluble in water, "forming solid salts with acids, which salts also I RUDOLPH- BERENDES. [Ll s;]

I Witnesses:

Orro Komo,

CHAs. J. WRIGHT. 

